Blar i forfatter "Singh, Rajwinder"

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    • Inflammatory response of macrophages and trophoblasts investigated using structured illumination microscopy and quantitative phase microscopy 

      Singh, Rajwinder; Wolfson, Deanna Lynn; Dubey, Vishesh; Ahmad, Azeem; Acharya, Ganesh; Mehta, Dalip Singh; Basnet, Purusotam; Ahluwalia, Balpreet Singh (Journal article; Tidsskriftartikkel; Peer reviewed, 2017-09)
      <i>Introduction</i>: The super-resolution capability of structured illumination microscopy (SIM) (100 nm) enables 3D imaging of mitochondria, and label-free quantitative phase microscopy (QPM) provides nanoscale quantitative phase values relating to cellular thickness and the refractive index of cellular content.

    • Investigation of inflammatory response of macrophages and trophoblasts using structured illumination microscopy 

      Singh, Rajwinder (Master thesis; Mastergradsoppgave, 2017-05-15)
      Approximately 800 women die from pregnancy or childbirth-related pregnancy complications around the world every day. One of the major reasons for these complications is inflammation following infection. Approximately 40% cases of preterm births occur due to microbial invasion in the genitourinary track. During inflammation, macrophages present at the feto-maternal junction release an increased amount ...

    • Multi-modal chip-based fluorescence and quantitative phase microscopy for studying inflammation in macrophages 

      Dubey, Vishesh; Ahmad, Azeem; Singh, Rajwinder; Wolfson, Deanna; Basnet, Purusotam; Acharya, Ganesh; Mehta, Dalip Singh; Ahluwalia, Balpreet Singh (Journal article; Tidsskriftartikkel; Peer reviewed, 2018-07-24)
      Total internal reflection fluorescence (TIRF) microscopy benefits from high-sensitivity, low background noise, low photo-toxicity and high-contrast imaging of sub-cellular structures close to the membrane surface. Although, TIRF microscopy provides high-contrast imaging it does not provide quantitative information about morphological features of the biological cells. Here, we propose an integrated ...

    • Quantitative assessment of morphology and sub-cellular changes in macrophages and trophoblasts during inflammation 

      Singh, Rajwinder; Dubey, Vishesh; Wolfson, Deanna; Ahmad, Azeem; Butola, Ankit; Acharya, Ganesh; Singh Mehta, Dalip; Basnet, Purusotam; Ahluwalia, Balpreet Singh (Journal article; Tidsskriftartikkel; Peer reviewed, 2020-06-12)
      In pregnancy during an inflammatory condition, macrophages present at the feto-maternal junction release an increased amount of nitric oxide (NO) and pro-inflammatory cytokines such as TNF-α and INF-γ, which can disturb the trophoblast functions and pregnancy outcome. Measurement of the cellular and sub-cellular morphological modifications associated with inflammatory responses are important in order ...